| 1. Round | 09/01/2022 | Coyotes de Tlaxcala | - | Atlético Morelia | 0:4 | ||||
| 2. Round | 12/01/2022 | Mineros de Zacatecas | - | Atlético Morelia | 1:2 | ||||
| 3. Round | 23/01/2022 | Atlético Morelia | - | CF Monterrey II | 1:0 | ||||
| 4. Round | 27/01/2022 | Cimarrones de Sonora | - | Atlético Morelia | 3:0 | ||||
| 5. Round | 29/01/2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:1 | ||||
| 6. Round | 04/02/2022 | Atlético Morelia | - | Tapatío | 1:2 |  |
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| 7. Round | 09/02/2022 | Correcaminos UAT | - | Atlético Morelia | 1:1 | ||||
| 8. Round | 18/02/2022 | Atlético Morelia | - | Cancún FC | 4:1 | ||||
| 10. Round | 04/03/2022 | Atlético Morelia | - | Dorados de Sinaloa | 2:0 | ||||
| 11. Round | 08/03/2022 | Club Celaya | - | Atlético Morelia | 2:2 | ||||
| 12. Round | 20/03/2022 | Atlético Morelia | - | TM Fútbol Club | 2:1 | ||||
| 13. Round | 23/03/2022 | Atlante | - | Atlético Morelia | 2:0 | ||||
| 14. Round | 27/03/2022 | Atlético Morelia | - | Leones Negros | 0:1 | |
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| 15. Round | 01/04/2022 | Tepatitlán | - | Atlético Morelia | 2:1 | ||||
| 16. Round | 07/04/2022 | Atlético Morelia | - | Venados FC | 2:2 | ||||
| 17. Round | 14/04/2022 | Pumas Tabasco | - | Atlético Morelia | 0:1 |
Chile