| 3. Round | 07/08/2021 | Shakhtar Donetsk | - | FK Oleksandriya | 1:2 |  |
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| 5. Round | 22/08/2021 | Kolos Kovalivka | - | FK Oleksandriya | 0:1 | ||||
| 6. Round | 27/08/2021 | Chernomorets Odessa | - | FK Oleksandriya | 2:2 | ||||
| 7. Round | 10/09/2021 | FK Oleksandriya | - | Inhulets Petrove | 1:0 | ||||
| 8. Round | 18/09/2021 | Dinamo Kiev | - | FK Oleksandriya | 1:0 | |
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| 9. Round | 25/09/2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 11. Round | 17/10/2021 | FK Oleksandriya | - | Vorskla Poltava | 1:2 | ||||
| 12. Round | 22/10/2021 | Desna Chernigov | - | FK Oleksandriya | 1:1 | ||||
| 13. Round | 31/10/2021 | Rukh Lviv | - | FK Oleksandriya | 0:0 | ||||
| 14. Round | 05/11/2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | |
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| 15. Round | 20/11/2021 | SK Dnipro-1 | - | FK Oleksandriya | 3:1 | |
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| 17. Round | 05/12/2021 | FK Oleksandriya | - | FC Mynai | 3:0 | ||||
| 18. Round | 11/12/2021 | FK Oleksandriya | - | Shakhtar Donetsk | 1:2 | |
Ukraine