| 1. Round | 25/07/2010 | Club San Luis | - | CF Monterrey | 1:1 |  |
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| 2. Round | 01/08/2010 | CF Monterrey | - | Estudiantes Tecos | 3:2 | ||||
| 6. Round | 29/08/2010 | CF Monterrey | - | Jaguares Chiapas | 1:1 | ||||
| 13. Round | 24/10/2010 | Santos Laguna | - | CF Monterrey | 1:2 | ||||
| 15. Round | 31/10/2010 | Monarcas Morelia | - | CF Monterrey | 0:2 | ||||
| 16. Round | 07/11/2010 | Puebla FC | - | CF Monterrey | 2:0 | ||||
| 17. Round | 13/11/2010 | CF Monterrey | - | Deportivo Guadalajara | 2:3 |  |
Mexico