| 2. Round | 01/08/2021 | FK Legion Dynamo Makhachkala | - | FK Yessentuki | 3:1 | ||||
| 5. Round | 20/08/2021 | FK Legion Dynamo Makhachkala | - | FK Mashuk KMV | 2:2 | ||||
| 6. Round | 29/08/2021 | Spartak Nalchik | - | FK Legion Dynamo Makhachkala | 1:1 | ||||
| 7. Round | 04/09/2021 | FK Legion Dynamo Makhachkala | - | FK Chayka | 0:1 |  |
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| 8. Round | 09/09/2021 | FK Legion Dynamo Makhachkala | - | Anzhi Makhachkala | 1:0 | ||||
| 9. Round | 13/09/2021 | FK Legion Dynamo Makhachkala | - | FK Druzhba | 1:2 | ||||
| 10. Round | 18/09/2021 | Alania-2 Vladikavkaz | - | FK Legion Dynamo Makhachkala | 0:2 | ||||
| 11. Round | 26/09/2021 | FK Legion Dynamo Makhachkala | - | Kuban-Holding Pavlovskaya | 0:0 | ||||
| 12. Round | 03/10/2021 | Forte Taganrog | - | FK Legion Dynamo Makhachkala | 2:1 | ||||
| 13. Round | 10/10/2021 | FK Legion Dynamo Makhachkala | - | FK Dinamo Makhachkala | 0:0 | ||||
| 14. Round | 17/10/2021 | Rotor-2 Volgograd | - | FK Legion Dynamo Makhachkala | 1:0 | ||||
| 15. Round | 23/10/2021 | FK Legion Dynamo Makhachkala | - | FK Tuapse | 0:1 | |
Russia