| 2. Round | 02/05/2021 | San Antonio FC | - | Colorado Springs Switchbacks | 3:0 | ||||
| 2. Round | 17/05/2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 | ||||
| 3. Round | 06/06/2021 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 3. Round | 17/06/2021 | New Mexico United | - | San Antonio FC | 2:0 | ||||
| 3. Round | 27/06/2021 | Real Monarchs SLC | - | San Antonio FC | 1:1 | ||||
| 4. Round | 17/07/2021 | Colorado Springs Switchbacks | - | San Antonio FC | 2:3 |  |
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| 5. Round | 29/08/2021 | San Antonio FC | - | El Paso Locomotive | 2:1 | ||||
| 6. Round | 05/09/2021 | San Antonio FC | - | Pittsburgh Riverhounds | 1:1 | ||||
| 6. Round | 26/09/2021 | San Antonio FC | - | New Mexico United | 0:1 | ||||
| 7. Round | 03/10/2021 | OKC Energy FC | - | San Antonio FC | 0:1 | |
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| 7. Round | 07/10/2021 | El Paso Locomotive | - | San Antonio FC | 3:3 |
USA