| 12. Round | 11/11/2000 | KAA Gent | - | KRC Harelbeke | 2:1 | ||||
| 13. Round | 19/11/2000 | KRC Harelbeke | - | Sint-Truidense VV | 0:4 | ||||
| 14. Round | 25/11/2000 | Excelsior Mouscron | - | KRC Harelbeke | 4:3 |  |
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| 15. Round | 03/12/2000 | KRC Harelbeke | - | KVC Westerlo | 0:4 | ||||
| 16. Round | 10/12/2000 | KRC Harelbeke | - | Sporting Lokeren | 1:6 | |
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| 17. Round | 16/12/2000 | KSK Beveren | - | KRC Harelbeke | 2:1 | ||||
| 22. Round | 10/02/2001 | Germinal Beerschot | - | KRC Harelbeke | 2:1 | ||||
| 23. Round | 18/02/2001 | KRC Harelbeke | - | RSC Anderlecht | 1:4 | ||||
| 25. Round | 11/03/2001 | KRC Harelbeke | - | Lierse SK (old) | 1:0 |
Iceland