2. Round | 13/02/2022 | Real Santa Cruz | - | CD Guabirá | 2:2 | ||||
3. Round | 18/02/2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
4. Round | 26/02/2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
5. Round | 06/03/2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
9. Round | 16/04/2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 |