| 1. Round | 11/09/2021 | FC Utrecht [Youth B] | - | PEC Zwolle [Youth B] | 5:0 | ||||
| 2. Round | 14/09/2021 | PEC Zwolle [Youth B] | - | Feyenoord [Youth B] | 1:2 | ||||
| 3. Round | 18/09/2021 | PEC Zwolle [Youth B] | - | NEC Nijmegen [Youth B] | 1:3 | ||||
| 4. Round | 25/09/2021 | AZ Alkmaar [Youth B] | - | PEC Zwolle [Youth B] | 4:0 | ||||
| 5. Round | 02/10/2021 | PEC Zwolle [Youth B] | - | PSV Eindhoven [Youth B] | 0:2 | ||||
| 6. Round | 16/10/2021 | sc Heerenveen [Youth B] | - | PEC Zwolle [Youth B] | 3:0 | ||||
| 7. Round | 23/10/2021 | PEC Zwolle [Youth B] | - | AFC Ajax [Youth B] | 0:2 | ||||
| 8. Round | 30/10/2021 | PSV Eindhoven [Youth B] | - | PEC Zwolle [Youth B] | 5:0 | ||||
| 11. Round | 27/11/2021 | Feyenoord [Youth B] | - | PEC Zwolle [Youth B] | 5:1 | ||||
| 14. Round | 16/02/2022 | AFC Ajax [Youth B] | - | PEC Zwolle [Youth B] | 4:1 |
Netherlands