| 3. Round | 03/06/2021 | Sporting Kansas City 2 | - | FC Tulsa | 4:1 | ||||
| 3. Round | 20/06/2021 | FC Tulsa | - | Louisville City FC | 2:3 | ||||
| 3. Round | 26/06/2021 | Rio Grande Valley FC | - | FC Tulsa | 1:2 | ||||
| 4. Round | 03/07/2021 | OKC Energy FC | - | FC Tulsa | 0:0 | ||||
| 4. Round | 11/07/2021 | FC Tulsa | - | Louisville City FC | 3:2 | ||||
| 4. Round | 18/07/2021 | FC Tulsa | - | OKC Energy FC | 1:2 | ||||
| 5. Round | 15/08/2021 | Louisville City FC | - | FC Tulsa | 2:1 | ||||
| 5. Round | 22/08/2021 | Birmingham Legion | - | FC Tulsa | 1:2 | ||||
| 7. Round | 21/10/2021 | FC Tulsa | - | Atlanta United II | 4:0 |
Nigeria