| 1. Round | 07/08/2021 | FC Lorient B | - | AS Vitré | 1:0 | ||||
| 2. Round | 14/08/2021 | AS Vitré | - | EA Guingamp B | 0:4 |  |
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| 5. Round | 04/09/2021 | Châteaubriant Voltigeurs | - | AS Vitré | 1:0 |  |
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| 6. Round | 11/09/2021 | AS Vitré | - | Vannes OC | 0:1 | ||||
| 7. Round | 18/09/2021 | US Granvillaise | - | AS Vitré | 1:1 | ||||
| 8. Round | 25/09/2021 | AS Vitré | - | SO Romorantin | 1:1 | ||||
| 9. Round | 09/10/2021 | FC Rouen 1899 | - | AS Vitré | 1:1 | ||||
| 10. Round | 23/10/2021 | SM Caen B | - | AS Vitré | 1:0 | ||||
| 22. Round | 19/03/2022 | SO Romorantin | - | AS Vitré | 1:1 | ||||
| 23. Round | 26/03/2022 | AS Vitré | - | FC Rouen 1899 | 2:2 | ||||
| 25. Round | 16/04/2022 | FC Versailles | - | AS Vitré | 3:0 | ||||
| 26. Round | 23/04/2022 | AS Vitré | - | US Saint-Malo | 2:2 | ||||
| 27. Round | 30/04/2022 | Stade Plabennec | - | AS Vitré | 2:2 | ||||
| 28. Round | 14/05/2022 | AS Vitré | - | St-Pryvé St-Hilaire | 0:3 | ||||
| 29. Round | 21/05/2022 | Blois Foot 41 | - | AS Vitré | 5:4 | ||||
| 30. Round | 28/05/2022 | AS Vitré | - | FC Lorient B | 0:5 |
France