| 1. Round | 05/01/2021 | Mamelodi Sundowns | - | Jwaneng Galaxy | 3:1 | ||||
| Group B | 13/02/2021 | Mamelodi Sundowns | - | Al Hilal Omdurman | 2:0 | ||||
| Group B | 28/02/2021 | CR Bélouizdad | - | Mamelodi Sundowns | 1:5 | ||||
| Group B | 06/03/2021 | TP Mazembe | - | Mamelodi Sundowns | 1:2 | ||||
| Group B | 16/03/2021 | Mamelodi Sundowns | - | TP Mazembe | 1:0 | ||||
| Group B | 02/04/2021 | Al Hilal Omdurman | - | Mamelodi Sundowns | 0:0 |  |
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| Quarter-finals | 15/05/2021 | Al Ahly SC | - | Mamelodi Sundowns | 2:0 | |
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| Quarter-finals | 22/05/2021 | Mamelodi Sundowns | - | Al Ahly SC | 1:1 |
South Africa