1st(1st leg) MC Alger - Wydad AC 1:1 (0:0)
2nd (2nd leg) Wydad AC - MC Alger 1:0 (0:0)
1st(1st leg): 14/05/2021 20:00 2nd (2nd leg): 22/05/2021 17:00 Winner: Wydad AC
1st(1st leg) CR Bélouizdad - Espérance de Tunis 2:0 (1:0)
2nd (2nd leg) Espérance de Tunis - CR Bélouizdad 3:2 (0:0, 2:0) pso
1st(1st leg): 15/05/2021 17:00 2nd (2nd leg): 22/05/2021 17:00 Winner: Espérance de Tunis
1st(1st leg) Kaizer Chiefs - Simba SC 4:0 (2:0)
2nd (2nd leg) Simba SC - Kaizer Chiefs 3:0 (1:0)
1st(1st leg): 15/05/2021 17:00 2nd (2nd leg): 22/05/2021 14:00 Winner: Kaizer Chiefs
1st(1st leg) Al-Ahly - Mamelodi Sundowns 2:0 (1:0)
2nd (2nd leg) Mamelodi Sundowns - Al-Ahly 1:1 (1:1)
1st(1st leg): 15/05/2021 20:00 2nd (2nd leg): 22/05/2021 14:00 Winner: Al-Ahly