| 1. Round | 16/09/2000 | Panachaiki GE | - | Skoda Xanthi | 1:1 | ||||
| 3. Round | 29/09/2000 | PAS Giannina | - | Skoda Xanthi | 1:1 |  |
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| 8. Round | 24/11/2000 | Panathinaikos | - | Skoda Xanthi | 3:0 | ||||
| 22. Round | 10/03/2001 | Paniliakos Pyrgos | - | Skoda Xanthi | 1:0 | ||||
| 24. Round | 31/03/2001 | PAOK Saloniki | - | Skoda Xanthi | 3:0 | ||||
| 25. Round | 07/04/2001 | Olympiakos Piraeus | - | Skoda Xanthi | 4:0 | ||||
| 27. Round | 28/04/2001 | Athinaikos | - | Skoda Xanthi | 2:2 | ||||
| 28. Round | 05/05/2001 | Skoda Xanthi | - | Ethnikos Asteras | 3:1 | ||||
| 29. Round | 20/05/2001 | Ionikos Nikea | - | Skoda Xanthi | 3:1 |
Greece