| 1. Round | 16/07/2021 | Radnik Bijeljina | - | Leotar Trebinje | 0:1 | ||||
| 2. Round | 25/07/2021 | Borac Banja Luka | - | Leotar Trebinje | 0:0 | ||||
| 3. Round | 30/07/2021 | Sloboda Tuzla | - | Leotar Trebinje | 1:0 | ||||
| 4. Round | 07/08/2021 | Leotar Trebinje | - | FK Tuzla City | 0:2 | ||||
| 5. Round | 13/08/2021 | Široki Brijeg | - | Leotar Trebinje | 2:0 | ||||
| 6. Round | 25/08/2021 | Leotar Trebinje | - | HŠK Posušje | 2:2 | ||||
| 7. Round | 28/08/2021 | Velež Mostar | - | Leotar Trebinje | 2:1 | ||||
| 8. Round | 11/09/2021 | Leotar Trebinje | - | Zrinjski Mostar | 0:1 |  |
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| 9. Round | 17/09/2021 | FK Sarajevo | - | Leotar Trebinje | 0:1 | |
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| 10. Round | 22/09/2021 | Leotar Trebinje | - | FK Rudar | 2:1 | ||||
| 12. Round | 02/10/2021 | Leotar Trebinje | - | Radnik Bijeljina | 1:0 | ||||
| 13. Round | 16/10/2021 | Leotar Trebinje | - | Borac Banja Luka | 1:1 | |
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| 15. Round | 31/10/2021 | FK Tuzla City | - | Leotar Trebinje | 4:0 | ||||
| 16. Round | 06/11/2021 | Leotar Trebinje | - | Široki Brijeg | 1:3 | ||||
| 17. Round | 21/11/2021 | HŠK Posušje | - | Leotar Trebinje | 1:0 | |
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| 18. Round | 27/11/2021 | Leotar Trebinje | - | Velež Mostar | 1:3 | |
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| 19. Round | 03/12/2021 | Zrinjski Mostar | - | Leotar Trebinje | 6:2 |
Bosnia-Herzegovina