| 3. Round | 24/07/2021 | FK Krasnodar 2 | - | Tekstilshchik Ivanovo | 1:1 | ||||
| 4. Round | 31/07/2021 | FK Krasnodar 2 | - | Olimp-Dolgoprudny | 2:0 | ||||
| 10. Round | 11/09/2021 | FK Krasnodar 2 | - | FK Tom Tomsk | 2:1 | ||||
| 11. Round | 15/09/2021 | FK Orenburg | - | FK Krasnodar 2 | 2:0 | ||||
| 14. Round | 29/09/2021 | FK Krasnodar 2 | - | Rotor Volgograd | 1:1 | ||||
| 15. Round | 03/10/2021 | FK Kamaz | - | FK Krasnodar 2 | 2:0 | ||||
| 18. Round | 17/10/2021 | Enisey Krasnoyarsk | - | FK Krasnodar 2 | 2:0 | ||||
| 19. Round | 23/10/2021 | FK Krasnodar 2 | - | Kuban Krasnodar | 1:2 | ||||
| 21. Round | 06/11/2021 | Tekstilshchik Ivanovo | - | FK Krasnodar 2 | 0:1 | ||||
| 22. Round | 13/11/2021 | Olimp-Dolgoprudny | - | FK Krasnodar 2 | 0:1 | ||||
| 23. Round | 17/11/2021 | FK Krasnodar 2 | - | SKA-Khabarovsk | 3:1 |  |
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| 25. Round | 27/11/2021 | FK Krasnodar 2 | - | Metallurg Lipetsk | 1:0 | ||||
| 26. Round | 08/03/2022 | FK Krasnodar 2 | - | Baltika Kaliningrad | 0:3 | ||||
| 34. Round | 23/04/2022 | FK Krasnodar 2 | - | Veles Moskva | 0:0 | ||||
| 37. Round | 14/05/2022 | Kuban Krasnodar | - | FK Krasnodar 2 | 0:0 |
Russia