| 1. Round | 24/08/2015 | Panetolikos | - | Panathinaikos | 1:2 |  |
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| 2. Round | 30/08/2015 | Panathinaikos | - | AEL Kalloni | 4:0 |  |
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| 3. Round | 13/09/2015 | Panionios GSS | - | Panathinaikos | 1:0 | |
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| 4. Round | 23/09/2015 | Panathinaikos | - | Levadiakos | 3:0 | ||||
| 5. Round | 27/09/2015 | Panathinaikos | - | Platanias Chanion | 1:0 | ||||
| 6. Round | 03/10/2015 | Skoda Xanthi | - | Panathinaikos | 0:1 | ||||
| 7. Round | 19/10/2015 | Panathinaikos | - | PAS Giannina | 3:1 | |
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| 8. Round | 25/10/2015 | PAOK Saloniki | - | Panathinaikos | 3:1 | |
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| 9. Round | 01/11/2015 | Panathinaikos | - | AEK Athen | 0:0 | ||||
| 12. Round | 28/11/2015 | AEP Iraklis FC | - | Panathinaikos | 1:0 | |
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| 14. Round | 13/12/2015 | Panathinaikos | - | Asteras Tripolis | 2:0 | ||||
| 16. Round | 04/01/2016 | Panathinaikos | - | Panetolikos | 4:2 | ||||
| 19. Round | 24/01/2016 | Levadiakos | - | Panathinaikos | 0:2 | ||||
| 20. Round | 31/01/2016 | Platanias Chanion | - | Panathinaikos | 2:3 | |
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| 21. Round | 06/02/2016 | Panathinaikos | - | Skoda Xanthi | 0:1 | ||||
| 26. Round | 13/03/2016 | Olympiakos Piraeus | - | Panathinaikos | 3:1 |
Greece