| 17. Round | 10/01/2010 | Panthrakikos | - | PAS Giannina | 1:2 |  |
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| 18. Round | 17/01/2010 | Panathinaikos | - | Panthrakikos | 2:0 | ||||
| 19. Round | 24/01/2010 | Panthrakikos | - | Skoda Xanthi | 1:1 | ||||
| 20. Round | 31/01/2010 | Panthrakikos | - | Ergotelis | 3:2 | ||||
| 21. Round | 07/02/2010 | Aris Saloniki | - | Panthrakikos | 0:2 | ||||
| 22. Round | 13/02/2010 | Panthrakikos | - | AEK Athen | 1:2 | ||||
| 23. Round | 21/02/2010 | AE Lárissa | - | Panthrakikos | 0:2 | ||||
| 24. Round | 28/02/2010 | Panthrakikos | - | AO Kavala | 1:3 | ||||
| 25. Round | 06/03/2010 | PAOK Saloniki | - | Panthrakikos | 3:0 | ||||
| 26. Round | 14/03/2010 | Panthrakikos | - | Panionios GSS | 0:1 | ||||
| 27. Round | 21/03/2010 | Levadiakos | - | Panthrakikos | 2:0 | ||||
| 28. Round | 28/03/2010 | Asteras Tripolis | - | Panthrakikos | 3:1 | ||||
| 29. Round | 11/04/2010 | Panthrakikos | - | Olympiakos Piraeus | 0:2 |
Greece