| 1. Round | 22/08/2021 | HSC'21 | - | EVV | 0:1 | ||||
| 6. Round | 26/09/2021 | HSC'21 | - | HVV Hollandia | 2:2 | ||||
| 8. Round | 10/10/2021 | HSC'21 | - | VV Hoogland | 4:1 |  |
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| 9. Round | 17/10/2021 | RKVV DEM | - | HSC'21 | 0:3 | ||||
| 10. Round | 24/10/2021 | HSC'21 | - | Blauw Geel '38 | 4:2 | |
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| 11. Round | 07/11/2021 | Unitas Gorinchem | - | HSC'21 | 1:0 | ||||
| 12. Round | 14/11/2021 | HSC'21 | - | RKSV Groene Ster | 0:1 | ||||
| 14. Round | 28/11/2021 | HSC'21 | - | OSS '20 | 4:0 | ||||
| 15. Round | 20/02/2022 | RKVV Westlandia | - | HSC'21 | 1:0 | ||||
| 16. Round | 27/02/2022 | HSC'21 | - | ADO '20 | 3:1 | |
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| 18. Round | 13/03/2022 | HSC'21 | - | VV Dongen | 4:3 | ||||
| 21. Round | 23/03/2022 | JOS Watergraafsmeer | - | HSC'21 | 1:0 | ||||
| 20. Round | 27/03/2022 | HSC'21 | - | Unitas Gorinchem | 4:0 |  |
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| 23. Round | 03/04/2022 | HSC'21 | - | USV Hercules | 0:3 | ||||
| 22. Round | 06/04/2022 | HSC'21 | - | OFC Oostzaan | 1:1 | ||||
| 24. Round | 10/04/2022 | Blauw Geel '38 | - | HSC'21 | 2:0 | ||||
| 19. Round | 13/04/2022 | HVV Hollandia | - | HSC'21 | 0:4 | ||||
| 25. Round | 16/04/2022 | HSC'21 | - | RKVV DEM | 1:0 | ||||
| 33. Round | 29/05/2022 | OSS '20 | - | HSC'21 | 3:0 | ||||
| 34. Round | 06/06/2022 | HSC'21 | - | RKVV Westlandia | 2:1 |
Netherlands