| 2. Round | 20/07/2022 | CF América [Women] | - | Santos Laguna [Women] | 2:0 | ||||
| 3. Round | 26/07/2022 | Santos Laguna [Women] | - | CF Pachuca [Women] | 3:2 |  |
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| 4. Round | 29/07/2022 | Deportivo Toluca [Women] | - | Santos Laguna [Women] | 2:0 | ||||
| 5. Round | 02/08/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:2 |  |
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| 7. Round | 16/08/2022 | Santos Laguna [Women] | - | Pumas UNAM [Women] | 1:2 | ||||
| 8. Round | 19/08/2022 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 3:1 | ||||
| 9. Round | 25/08/2022 | Santos Laguna [Women] | - | UANL Tigres [Women] | 1:4 | ||||
| 10. Round | 27/08/2022 | Atlas Guadalajara [Women] | - | Santos Laguna [Women] | 2:1 | ||||
| 11. Round | 13/09/2022 | Santos Laguna [Women] | - | Club Tijuana [Women] | 1:2 |
Mexico