| 7. Round | 15/09/2024 | Santos Laguna | - | CF Monterrey | 0:2 | ||||
| 11. Round | 07/10/2024 | Santos Laguna | - | FC Juárez | 0:2 | ||||
| 12. Round | 20/10/2024 | CF América | - | Santos Laguna | 3:0 | ||||
| 13. Round | 23/10/2024 | Santos Laguna | - | CF Pachuca | 1:1 | ||||
| 14. Round | 26/10/2024 | Santos Laguna | - | Mazatlán FC | 0:0 | ||||
| 15. Round | 03/11/2024 | Cruz Azul | - | Santos Laguna | 2:0 | ||||
| 16. Round | 06/11/2024 | Santos Laguna | - | Deportivo Guadalajara | 0:2 | ||||
| 17. Round | 09/11/2024 | Gallos Blancos | - | Santos Laguna | 3:2 |
Mexico