| 2. Round | 11/04/2010 | Chicago Fire | - | San Jose Earthquakes | 1:2 | ||||
| 2. Round | 18/04/2010 | San Jose Earthquakes | - | New England Revolution | 2:0 | ||||
| 2. Round | 25/04/2010 | CD Chivas | - | San Jose Earthquakes | 3:2 |  |
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| 3. Round | 22/05/2010 | Seattle Sounders | - | San Jose Earthquakes | 0:1 | ||||
| 4. Round | 03/06/2010 | San Jose Earthquakes | - | Columbus Crew | 2:2 | ||||
| 4. Round | 26/06/2010 | Real Salt Lake | - | San Jose Earthquakes | 0:0 | ||||
| 5. Round | 04/07/2010 | San Jose Earthquakes | - | D.C. United | 1:1 | ||||
| 8. Round | 21/10/2010 | San Jose Earthquakes | - | CD Chivas | 3:0 |
USA