| 4. Round | 22/07/2021 | Colorado Rapids | - | FC Dallas | 2:0 | ||||
| 4. Round | 25/07/2021 | Real Salt Lake | - | Colorado Rapids | 3:0 | ||||
| 5. Round | 01/08/2021 | Austin FC | - | Colorado Rapids | 0:1 | ||||
| 5. Round | 08/08/2021 | Colorado Rapids | - | Sporting Kansas City | 0:0 |  |
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| 5. Round | 18/08/2021 | Los Angeles Galaxy | - | Colorado Rapids | 1:2 | ||||
| 6. Round | 05/09/2021 | San Jose Earthquakes | - | Colorado Rapids | 0:1 | ||||
| 6. Round | 30/09/2021 | Colorado Rapids | - | Austin FC | 3:0 | ||||
| 7. Round | 24/10/2021 | Colorado Rapids | - | Portland Timbers | 2:0 | ||||
| 7. Round | 28/10/2021 | New England Revolution | - | Colorado Rapids | 1:0 | ||||
| 7. Round | 31/10/2021 | Houston Dynamo | - | Colorado Rapids | 0:1 | ||||
| 8. Round | 07/11/2021 | Colorado Rapids | - | Los Angeles FC | 5:2 |
USA