| 1. Round | 07/08/2011 | NAC Breda | - | FC Twente | 0:1 | ||||
| 2. Round | 13/08/2011 | FC Twente | - | AZ Alkmaar | 2:0 | ||||
| 4. Round | 27/08/2011 | FC Twente | - | VVV-Venlo | 4:1 | ||||
| 5. Round | 10/09/2011 | Roda JC Kerkrade | - | FC Twente | 2:1 | ||||
| 8. Round | 02/10/2011 | FC Twente | - | SBV Excelsior | 2:2 | ||||
| 15. Round | 04/12/2011 | FC Utrecht | - | FC Twente | 2:6 |  |
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| 17. Round | 18/12/2011 | Feyenoord | - | FC Twente | 3:2 |
Netherlands