| 3. Round | 20/08/2021 | FC Den Bosch | - | Jong Ajax | 2:3 | ||||
| 6. Round | 10/09/2021 | Jong PSV | - | Jong Ajax | 3:1 | ||||
| 17. Round | 26/11/2021 | De Graafschap | - | Jong Ajax | 1:3 | ||||
| 20. Round | 20/12/2021 | Jong Ajax | - | Helmond Sport | 1:1 | ||||
| 21. Round | 10/01/2022 | FC Utrecht (J) | - | Jong Ajax | 0:2 |  |
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| 25. Round | 04/02/2022 | Jong Ajax | - | AZ Alkmaar (J) | 2:1 | ||||
| 29. Round | 07/03/2022 | Jong Ajax | - | ADO Den Haag | 6:3 | ||||
| 30. Round | 11/03/2022 | FC Dordrecht | - | Jong Ajax | 3:3 |  |
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| 33. Round | 01/04/2022 | NAC Breda | - | Jong Ajax | 0:0 | ||||
| 35. Round | 16/04/2022 | FC Volendam | - | Jong Ajax | 3:1 | |
Cameroon