| 1. Round | 19/09/2020 | Alacranes de Durango | - | Atlético San Luis II | 2:0 | ||||
| 2. Round | 26/09/2020 | Atlético San Luis II | - | Cimarrones de Sonora II | 2:1 | ||||
| 3. Round | 02/10/2020 | Saltillo FC | - | Atlético San Luis II | 1:3 | ||||
| 4. Round | 10/10/2020 | Atlético San Luis II | - | Leones Negros II | 0:2 | ||||
| 5. Round | 15/10/2020 | Tecos Fútbol Club | - | Atlético San Luis II | 2:0 | ||||
| 17. Round | 20/02/2021 | Mineros de Fresnillo FC | - | Atlético San Luis II | 1:2 | ||||
| 18. Round | 05/03/2021 | Atlético San Luis II | - | Mazorqueros | 2:1 | ||||
| 19. Round | 14/03/2021 | Colima FC | - | Atlético San Luis II | 2:0 | ||||
| 20. Round | 21/03/2021 | Reboceros de La Piedad | - | Atlético San Luis II | 1:0 |  |
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| 21. Round | 03/04/2021 | Atlético San Luis II | - | Gavilanes de Matamoros | 1:1 |  |
Colombia