| 1. Round | 03/09/2022 | NEC Nijmegen [U21] | - | Vitesse [U21] | 0:2 | ||||
| 2. Round | 10/09/2022 | Roda JC Kerkrade [U21] | - | NEC Nijmegen [U21] | 2:3 |  |
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| 9. Round | 05/11/2022 | NEC Nijmegen [U21] | - | Roda JC Kerkrade [U21] | 3:1 | |
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| 10. Round | 12/11/2022 | Go Ahead Eagles [U21] | - | NEC Nijmegen [U21] | 3:1 | ||||
| 12. Round | 26/11/2022 | NEC Nijmegen [U21] | - | VVV-Venlo [U21] | 5:0 | |
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| 13. Round | 06/12/2022 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 2:0 | ||||
| 11. Round | 10/12/2022 | NEC Nijmegen [U21] | - | NAC Breda [U21] | 3:4 | |
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| 14. Round | 17/12/2022 | NEC Nijmegen [U21] | - | FC Den Bosch [U21] | 2:1 | |
Netherlands