| 1. Round | 11/09/2021 | PSV Eindhoven [U18] | - | PEC Zwolle [U18] | 0:0 | ||||
| 4. Round | 25/09/2021 | FC Utrecht [U18] | - | PSV Eindhoven [U18] | 2:4 | ||||
| 5. Round | 02/10/2021 | PSV Eindhoven [U18] | - | sc Heerenveen [U18] | 5:0 | ||||
| 6. Round | 16/10/2021 | Sparta Rotterdam [U18] | - | PSV Eindhoven [U18] | 0:5 | ||||
| 7. Round | 23/10/2021 | PSV Eindhoven [U18] | - | AZ Alkmaar [U18] | 1:0 | ||||
| 8. Round | 31/10/2021 | sc Heerenveen [U18] | - | PSV Eindhoven [U18] | 1:2 | ||||
| 11. Round | 30/11/2021 | PSV Eindhoven [U18] | - | AFC Ajax [U18] | 3:2 | ||||
| 9. Round | 04/12/2021 | PSV Eindhoven [U18] | - | FC Utrecht [U18] | 6:2 | ||||
| 14. Round | 18/12/2021 | PSV Eindhoven [U18] | - | Sparta Rotterdam [U18] | 6:1 | ||||
| 13. Round | 12/02/2022 | Feyenoord [U18] | - | PSV Eindhoven [U18] | 4:4 |  |
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| 12. Round | 26/02/2022 | PEC Zwolle [U18] | - | PSV Eindhoven [U18] | 0:2 |
Netherlands