| 1. Round | 23/01/2010 | Atenas | - | Defensor Sporting | 3:1 |  |
|||
| 2. Round | 31/01/2010 | Defensor Sporting | - | Danubio | 0:1 | ||||
| 3. Round | 06/02/2010 | Nacional | - | Defensor Sporting | 0:1 | ||||
| 4. Round | 13/02/2010 | Defensor Sporting | - | Central Español | 3:4 | ||||
| 5. Round | 21/02/2010 | Fénix | - | Defensor Sporting | 3:0 | ||||
| 6. Round | 27/02/2010 | Defensor Sporting | - | Rampla Juniors | 2:1 | ||||
| 10. Round | 28/03/2010 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 14. Round | 25/04/2010 | Defensor Sporting | - | Montevideo Wanderers | 2:0 | ||||
| 15. Round | 02/05/2010 | Liverpool | - | Defensor Sporting | 3:0 |
Uruguay