| 1. Round | 18/01/2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Round | 28/01/2021 | Peñarol | - | Defensor Sporting | 1:2 | ||||
| 10. Round | 28/02/2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 11. Round | 08/03/2021 | Nacional | - | Defensor Sporting | 2:1 | ||||
| 12. Round | 12/03/2021 | Defensor Sporting | - | Boston River | 1:2 |  |
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| 13. Round | 18/03/2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 | ||||
| 14. Round | 25/03/2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Round | 29/03/2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
Uruguay