| 1. Round | 22/02/2025 | Los Angeles FC | - | Minnesota United FC | 1:0 | ||||
| 2. Round | 02/03/2025 | Minnesota United FC | - | CF Montréal | 1:0 |  |
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| 3. Round | 09/03/2025 | San Jose Earthquakes | - | Minnesota United FC | 0:1 | ||||
| 4. Round | 16/03/2025 | Sporting Kansas City | - | Minnesota United FC | 3:3 |  |
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| 6. Round | 30/03/2025 | Minnesota United FC | - | Real Salt Lake | 2:0 | |
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| 7. Round | 06/04/2025 | New York City FC | - | Minnesota United FC | 1:2 | |
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| 8. Round | 12/04/2025 | Toronto FC | - | Minnesota United FC | 0:0 | ||||
| 9. Round | 20/04/2025 | Minnesota United FC | - | FC Dallas | 0:0 | |
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| 10. Round | 27/04/2025 | Minnesota United FC | - | Vancouver Whitecaps | 1:3 | ||||
| 11. Round | 04/05/2025 | Austin FC | - | Minnesota United FC | 0:3 | ||||
| 12. Round | 10/05/2025 | Minnesota United FC | - | Inter Miami CF | 4:1 | ||||
| 13. Round | 15/05/2025 | Houston Dynamo | - | Minnesota United FC | 2:0 | ||||
| 14. Round | 18/05/2025 | Minnesota United FC | - | St. Louis City SC | 3:0 | |
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| 15. Round | 25/05/2025 | Minnesota United FC | - | Austin FC | 1:1 | ||||
| 16. Round | 29/05/2025 | Vancouver Whitecaps | - | Minnesota United FC | 0:0 | ||||
| 17. Round | 01/06/2025 | Seattle Sounders | - | Minnesota United FC | 2:3 | |
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