| 1. Round | 28/02/2022 | Houston Dynamo | - | Real Salt Lake | 0:0 | ||||
| 2. Round | 05/03/2022 | Real Salt Lake | - | Seattle Sounders | 1:0 | ||||
| 2. Round | 13/03/2022 | New England Revolution | - | Real Salt Lake | 2:3 |  |
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| 2. Round | 20/03/2022 | Real Salt Lake | - | Nashville SC | 2:1 | |
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| 2. Round | 26/03/2022 | Sporting Kansas City | - | Real Salt Lake | 1:0 | ||||
| 3. Round | 03/04/2022 | Colorado Rapids | - | Real Salt Lake | 1:1 | |
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| 3. Round | 10/04/2022 | Real Salt Lake | - | Toronto FC | 2:2 | ||||
| 3. Round | 17/04/2022 | New York City FC | - | Real Salt Lake | 6:0 | |
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| 3. Round | 24/04/2022 | Portland Timbers | - | Real Salt Lake | 0:0 | ||||
| 3. Round | 30/04/2022 | Real Salt Lake | - | Los Angeles Galaxy | 1:0 | ||||
| 4. Round | 08/05/2022 | Nashville SC | - | Real Salt Lake | 2:0 | ||||
| 4. Round | 15/05/2022 | Real Salt Lake | - | Austin FC | 2:1 | ||||
| 5. Round | 19/06/2022 | Real Salt Lake | - | San Jose Earthquakes | 2:0 | |
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| 6. Round | 14/07/2022 | Atlanta United FC | - | Real Salt Lake | 2:1 |
USA