| 2. Round | 21/05/2022 | Portland Thorns [Women] | - | Houston Dash [Women] | 0:2 |  |
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| 3. Round | 04/06/2022 | Portland Thorns [Women] | - | Angel City FC [Women] | 3:0 | ||||
| 3. Round | 13/06/2022 | Houston Dash [Women] | - | Portland Thorns [Women] | 0:4 | ||||
| 3. Round | 19/06/2022 | Portland Thorns [Women] | - | Orlando Pride [Women] | 6:0 |  |
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| 4. Round | 02/07/2022 | Angel City FC [Women] | - | Portland Thorns [Women] | 1:1 | ||||
| 4. Round | 10/07/2022 | OL Reign [Women] | - | Portland Thorns [Women] | 2:2 | ||||
| 4. Round | 17/07/2022 | Portland Thorns [Women] | - | NJ/NY Gotham FC [Women] | 5:0 | |
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| 4. Round | 30/07/2022 | Racing Louisville [Women] | - | Portland Thorns [Women] | 1:2 | ||||
| 5. Round | 25/08/2022 | NC Courage [Women] | - | Portland Thorns [Women] | 3:1 | ||||
| 6. Round | 25/09/2022 | Portland Thorns [Women] | - | Chicago Red Stars [Women] | 3:0 | |
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| 7. Round | 01/10/2022 | NJ/NY Gotham FC [Women] | - | Portland Thorns [Women] | 3:3 |
USA