| 4. Round | 15/08/2021 | FK Mashuk KMV | - | FK Biolog Novokubansk | 2:0 | ||||
| 5. Round | 20/08/2021 | FK Legion Dynamo Makhachkala | - | FK Mashuk KMV | 2:2 | ||||
| 7. Round | 04/09/2021 | FK Mashuk KMV | - | Spartak Nalchik | 1:2 | ||||
| 8. Round | 08/09/2021 | FK Chayka | - | FK Mashuk KMV | 3:0 |  |
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| 10. Round | 18/09/2021 | FK Druzhba | - | FK Mashuk KMV | 1:1 | ||||
| 11. Round | 26/09/2021 | FK Mashuk KMV | - | Alania-2 Vladikavkaz | 4:1 | ||||
| 12. Round | 03/10/2021 | Kuban-Holding Pavlovskaya | - | FK Mashuk KMV | 1:0 | |
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| 13. Round | 10/10/2021 | FK Mashuk KMV | - | Forte Taganrog | 0:2 | ||||
| 14. Round | 17/10/2021 | FK Dinamo Makhachkala | - | FK Mashuk KMV | 2:1 |  |
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| 15. Round | 23/10/2021 | FK Mashuk KMV | - | Rotor-2 Volgograd | 1:1 | ||||
| 19. Round | 27/10/2021 | FK Mashuk KMV | - | FK Yessentuki | 7:0 | |
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| 16. Round | 01/11/2021 | FK Tuapse | - | FK Mashuk KMV | 3:0 | |
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| 17. Round | 06/11/2021 | FK Mashuk KMV | - | FK SKA Rostov | 0:2 |
Russia