| 1. Round | 12/03/2022 | Loudoun United | - | Indy Eleven | 1:0 | ||||
| 2. Round | 10/04/2022 | Loudoun United | - | Louisville City FC | 0:2 | ||||
| 3. Round | 15/05/2022 | Detroit City FC | - | Loudoun United | 4:2 | ||||
| 3. Round | 22/05/2022 | Loudoun United | - | Memphis 901 | 0:3 |  |
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| 6. Round | 01/09/2022 | Memphis 901 | - | Loudoun United | 0:1 | ||||
| 7. Round | 05/09/2022 | Loudoun United | - | Pittsburgh Riverhounds | 1:2 | ||||
| 7. Round | 18/09/2022 | Louisville City FC | - | Loudoun United | 4:2 |  |
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| 7. Round | 22/09/2022 | Loudoun United | - | Hartford Athletic | 3:0 | |
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| 7. Round | 25/09/2022 | Indy Eleven | - | Loudoun United | 1:0 | ||||
| 8. Round | 15/10/2022 | Charleston Battery | - | Loudoun United | 1:1 |
USA