1. Round | 24/07/2021 | FK Dinamo Makhachkala | - | FK Druzhba | 3:0 | ||||
2. Round | 01/08/2021 | FK Druzhba | - | Rotor-2 Volgograd | 0:2 | ||||
3. Round | 07/08/2021 | FK Tuapse | - | FK Druzhba | 3:0 | ||||
4. Round | 15/08/2021 | FK Druzhba | - | FK SKA Rostov | 1:4 | ||||
5. Round | 21/08/2021 | Dinamo Stavropol | - | FK Druzhba | 1:2 | ||||
6. Round | 29/08/2021 | FK Druzhba | - | Chernomorets Novorossisk | 0:1 | ||||
7. Round | 04/09/2021 | FK Yessentuki | - | FK Druzhba | 2:1 | ||||
8. Round | 08/09/2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 | ||||
9. Round | 13/09/2021 | FK Legion Dynamo Makhachkala | - | FK Druzhba | 1:2 | ||||
10. Round | 18/09/2021 | FK Druzhba | - | FK Mashuk KMV | 1:1 | ||||
12. Round | 03/10/2021 | FK Druzhba | - | FK Chayka | 0:2 | ||||
13. Round | 10/10/2021 | Anzhi Makhachkala | - | FK Druzhba | 0:0 | ||||
16. Round | 31/10/2021 | Kuban-Holding Pavlovskaya | - | FK Druzhba | 3:1 | ||||
17. Round | 06/11/2021 | FK Druzhba | - | Forte Taganrog | 1:2 | ||||
18. Round | 13/11/2021 | Rotor-2 Volgograd | - | FK Druzhba | 0:0 | ||||
19. Round | 19/11/2021 | FK Druzhba | - | FK Tuapse | 1:0 | ||||
20. Round | 06/03/2022 | FK SKA Rostov | - | FK Druzhba | 1:0 | ||||
23. Round | 27/03/2022 | FK Druzhba | - | FK Yessentuki | 0:0 |