| 1. Round | 06/08/2021 | Telstar | - | FC Emmen | 1:1 | ||||
| 2. Round | 13/08/2021 | FC Emmen | - | FC Eindhoven | 0:1 | ||||
| 5. Round | 03/09/2021 | Helmond Sport | - | FC Emmen | 1:0 | ||||
| 8. Round | 24/09/2021 | FC Emmen | - | FC Den Bosch | 2:0 | ||||
| 9. Round | 01/10/2021 | FC Utrecht (J) | - | FC Emmen | 0:1 | ||||
| 11. Round | 15/10/2021 | TOP Oss | - | FC Emmen | 1:2 | ||||
| 15. Round | 22/11/2021 | AZ Alkmaar (J) | - | FC Emmen | 0:0 | ||||
| 17. Round | 29/11/2021 | FC Emmen | - | Almere City FC | 3:0 | ||||
| 18. Round | 06/12/2021 | Jong Ajax | - | FC Emmen | 1:0 | ||||
| 21. Round | 08/01/2022 | FC Den Bosch | - | FC Emmen | 0:2 | ||||
| 23. Round | 22/01/2022 | FC Emmen | - | NAC Breda | 2:0 | ||||
| 36. Round | 22/04/2022 | FC Emmen | - | Roda JC Kerkrade | 2:0 |
Netherlands