| 1. Round | 06/11/2021 | AS Rhodos | - | Ergotelis | 1:0 | ||||
| 2. Round | 14/11/2021 | Asteras Vlachioti | - | AS Rhodos | 0:0 |  |
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| 6. Round | 05/12/2021 | OFI Ierapetra | - | AS Rhodos | 1:1 | ||||
| 8. Round | 15/12/2021 | AO Egaleo | - | AS Rhodos | 3:1 | |
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| 9. Round | 19/12/2021 | AS Rhodos | - | Irodotos | 1:0 |  |
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| 10. Round | 29/12/2021 | Levadiakos | - | AS Rhodos | 5:0 | ||||
| 16. Round | 30/01/2022 | AS Rhodos | - | Panathinaikos II | 0:0 | ||||
| 7. Round | 02/02/2022 | AS Rhodos | - | GS Kallithea | 0:1 | ||||
| 17. Round | 06/02/2022 | AE Karaiskakis | - | AS Rhodos | 2:1 | ||||
| 15. Round | 09/02/2022 | PS Kalamata | - | AS Rhodos | 3:1 | ||||
| 26. Round | 27/03/2022 | Irodotos | - | AS Rhodos | 0:0 | ||||
| 27. Round | 30/03/2022 | AS Rhodos | - | Levadiakos | 0:4 | ||||
| 29. Round | 06/04/2022 | AO Episkopi | - | AS Rhodos | 4:2 | ||||
| 30. Round | 10/04/2022 | AS Rhodos | - | AE Kifisias | 1:3 | |
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| 31. Round | 13/04/2022 | AEK Athen II | - | AS Rhodos | 5:0 |
Greece