| Qual. 2. Round | 17/10/2021 | AS Maniema Union | - | Mamelodi Sundowns | 2:2 |  |
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| Qual. 2. Round | 24/10/2021 | Mamelodi Sundowns | - | AS Maniema Union | 2:0 | ||||
| Group A | 11/02/2022 | Mamelodi Sundowns | - | Al Hilal Omdurman | 1:0 | |
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| Group A | 19/02/2022 | Al Merrikh SC | - | Mamelodi Sundowns | 0:0 | ||||
| Group A | 26/02/2022 | Al Ahly SC | - | Mamelodi Sundowns | 0:1 | ||||
| Group A | 12/03/2022 | Mamelodi Sundowns | - | Al Ahly SC | 1:0 | ||||
| Group A | 19/03/2022 | Al Hilal Omdurman | - | Mamelodi Sundowns | 2:4 | ||||
| Group A | 02/04/2022 | Mamelodi Sundowns | - | Al Merrikh SC | 3:0 | ||||
| Quarter-finals | 16/04/2022 | Petro Atlético | - | Mamelodi Sundowns | 2:1 | ||||
| Quarter-finals | 23/04/2022 | Mamelodi Sundowns | - | Petro Atlético | 1:1 |
South Africa