| 12. Round | 11/01/2022 | Milton Keynes Dons | - | AFC Wimbledon | 1:0 | ||||
| 28. Round | 15/01/2022 | Portsmouth FC | - | Milton Keynes Dons | 1:2 |  |
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| 29. Round | 22/01/2022 | Milton Keynes Dons | - | Doncaster Rovers | 0:1 | ||||
| 23. Round | 25/01/2022 | Burton Albion | - | Milton Keynes Dons | 0:1 | ||||
| 30. Round | 29/01/2022 | Wycombe Wanderers | - | Milton Keynes Dons | 0:1 | ||||
| 31. Round | 05/02/2022 | Milton Keynes Dons | - | Lincoln City | 2:1 | ||||
| 33. Round | 12/02/2022 | Milton Keynes Dons | - | Ipswich Town | 0:0 | ||||
| 35. Round | 22/02/2022 | Charlton Athletic | - | Milton Keynes Dons | 0:2 | ||||
| 25. Round | 08/03/2022 | Milton Keynes Dons | - | Cheltenham Town | 3:1 | ||||
| 38. Round | 12/03/2022 | Milton Keynes Dons | - | Wigan Athletic | 1:1 | ||||
| 41. Round | 02/04/2022 | Milton Keynes Dons | - | Shrewsbury Town | 2:0 | ||||
| 40. Round | 05/04/2022 | Milton Keynes Dons | - | Crewe Alexandra | 2:1 | ||||
| 42. Round | 09/04/2022 | AFC Wimbledon | - | Milton Keynes Dons | 1:1 | ||||
| 43. Round | 16/04/2022 | Milton Keynes Dons | - | Sheffield Wednesday | 2:3 | ||||
| 44. Round | 19/04/2022 | Oxford United | - | Milton Keynes Dons | 1:0 | ||||
| 45. Round | 23/04/2022 | Milton Keynes Dons | - | Morecambe FC | 2:0 |
Canada
Romania