| 2. Round | 15/08/2020 | Sporting Charleroi | - | KV Oostende | 1:0 | ||||
| 3. Round | 24/08/2020 | Sint-Truidense VV | - | KV Oostende | 0:0 | ||||
| 4. Round | 28/08/2020 | KV Oostende | - | RSC Anderlecht | 2:2 | ||||
| 5. Round | 12/09/2020 | KV Mechelen | - | KV Oostende | 0:1 | ||||
| 6. Round | 19/09/2020 | KV Oostende | - | Oud-Heverlee Leuven | 3:1 | ||||
| 7. Round | 28/09/2020 | KRC Genk | - | KV Oostende | 2:2 |  |
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| 8. Round | 04/10/2020 | KV Oostende | - | Royal Excel Mouscron | 3:0 | ||||
| 10. Round | 25/10/2020 | KV Oostende | - | SV Zulte Waregem | 3:0 | ||||
| 11. Round | 01/11/2020 | Standard Liège | - | KV Oostende | 1:0 | ||||
| 12. Round | 08/11/2020 | KV Oostende | - | Club Brugge KV | 1:3 | |
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| 13. Round | 21/11/2020 | KV Oostende | - | Royal Antwerp FC | 1:1 | ||||
| 9. Round | 24/11/2020 | Waasland-Beveren | - | KV Oostende | 2:0 | ||||
| 18. Round | 15/12/2020 | RSC Anderlecht | - | KV Oostende | 2:1 | |
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| 32. Round | 03/04/2021 | KV Oostende | - | Waasland-Beveren | 0:2 | ||||
| 33. Round | 11/04/2021 | K Beerschot VA | - | KV Oostende | 1:2 | ||||
| 34. Round | 18/04/2021 | KV Oostende | - | Cercle Brugge | 1:1 | |
France
Cameroon