1. Round | 12/09/2021 | Volos NFC | - | Lamia | 2:1 | ||||
2. Round | 19/09/2021 | Lamia | - | Olympiakos Piraeus | 1:2 | ||||
3. Round | 22/09/2021 | AEK Athen | - | Lamia | 1:0 | ||||
6. Round | 18/10/2021 | Lamia | - | Aris Saloniki | 0:1 | ||||
7. Round | 24/10/2021 | OFI Heraklion | - | Lamia | 0:0 | ||||
8. Round | 31/10/2021 | Lamia | - | Atromitos | 2:2 | ||||
9. Round | 07/11/2021 | Asteras Tripolis | - | Lamia | 0:1 | ||||
10. Round | 22/11/2021 | Lamia | - | Panathinaikos | 1:3 | ||||
13. Round | 12/12/2021 | PAOK Saloniki | - | Lamia | 2:1 | ||||
14. Round | 15/12/2021 | Lamia | - | Volos NFC | 2:2 | ||||
15. Round | 19/12/2021 | Olympiakos Piraeus | - | Lamia | 1:0 | ||||
16. Round | 05/01/2022 | Lamia | - | AEK Athen | 0:2 | ||||
18. Round | 15/01/2022 | Lamia | - | Ionikos Nikea | 2:1 | ||||
19. Round | 23/01/2022 | Aris Saloniki | - | Lamia | 0:0 | ||||
20. Round | 29/01/2022 | Lamia | - | OFI Heraklion | 2:1 | ||||
21. Round | 10/02/2022 | Atromitos | - | Lamia | 3:1 | ||||
23. Round | 13/02/2022 | Panathinaikos | - | Lamia | 2:0 | ||||
17. Round | 16/02/2022 | Panetolikos | - | Lamia | 1:0 | ||||
24. Round | 20/02/2022 | Lamia | - | Apollon Smyrnis | 1:2 | ||||
22. Round | 23/02/2022 | Lamia | - | Asteras Tripolis | 0:2 |