| 10. Round | 01/04/2023 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 11. Round | 11/04/2023 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 12. Round | 14/04/2023 | Guaraní | - | Libertad | 0:0 | ||||
| 13. Round | 17/04/2023 | Sportivo Ameliano | - | Guaraní | 1:1 | ||||
| 14. Round | 25/04/2023 | Guaraní | - | Cerro Porteño | 0:3 | ||||
| 16. Round | 06/05/2023 | Sportivo Luqueño | - | Guaraní | 3:0 | ||||
| 17. Round | 14/05/2023 | Guaraní | - | Club Nacional | 2:2 | ||||
| 18. Round | 18/05/2023 | Tacuary | - | Guaraní | 1:3 | ||||
| 19. Round | 22/05/2023 | Guaraní | - | Sportivo Trinidense | 0:2 |
Paraguay