| 1. Round | 01/08/2022 | Liverpool | - | Defensor Sporting | 1:3 |  |
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| 3. Round | 14/08/2022 | Liverpool | - | Nacional | 0:1 | |
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| 6. Round | 20/08/2022 | Rentistas | - | Liverpool | 0:2 |  |
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| 5. Round | 28/08/2022 | Liverpool | - | Deportivo Maldonado | 1:1 | |
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| 4. Round | 03/09/2022 | Danubio | - | Liverpool | 1:1 | |
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| 7. Round | 09/09/2022 | Liverpool | - | Cerrito | 3:0 | |
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| 8. Round | 15/09/2022 | Liverpool | - | Peñarol | 0:1 | ||||
| 9. Round | 19/09/2022 | Montevideo City Torque | - | Liverpool | 0:2 | ||||
| 10. Round | 24/09/2022 | Liverpool | - | Montevideo Wanderers | 1:1 | |
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| 11. Round | 01/10/2022 | Plaza Colonia | - | Liverpool | 1:3 | |
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| 12. Round | 09/10/2022 | Liverpool | - | Boston River | 3:2 | ||||
| 13. Round | 13/10/2022 | River Plate | - | Liverpool | 0:1 | |
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| 15. Round | 23/10/2022 | Fénix | - | Liverpool | 0:3 | |
Uruguay
Italy