| 1. Round | 05/08/2022 | VVV-Venlo | - | Almere City FC | 3:0 | ||||
| 2. Round | 12/08/2022 | De Graafschap | - | VVV-Venlo | 1:2 |  |
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| 3. Round | 21/08/2022 | VVV-Venlo | - | PEC Zwolle | 0:4 | ||||
| 4. Round | 26/08/2022 | TOP Oss | - | VVV-Venlo | 1:2 | |
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| 5. Round | 02/09/2022 | VVV-Venlo | - | FC Utrecht (J) | 2:1 |  |
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| 6. Round | 09/09/2022 | Heracles Almelo | - | VVV-Venlo | 5:3 | ||||
| 7. Round | 16/09/2022 | VVV-Venlo | - | Jong PSV | 1:1 | ||||
| 8. Round | 23/09/2022 | VVV-Venlo | - | Telstar | 1:1 | ||||
| 9. Round | 30/09/2022 | NAC Breda | - | VVV-Venlo | 1:2 | ||||
| 10. Round | 07/10/2022 | Roda JC Kerkrade | - | VVV-Venlo | 4:1 | ||||
| 12. Round | 24/10/2022 | Jong Ajax | - | VVV-Venlo | 1:1 | ||||
| 13. Round | 28/10/2022 | VVV-Venlo | - | AZ Alkmaar (J) | 1:2 | ||||
| 14. Round | 04/11/2022 | ADO Den Haag | - | VVV-Venlo | 2:3 | ||||
| 15. Round | 11/11/2022 | VVV-Venlo | - | Willem II | 0:0 | ||||
| 16. Round | 19/11/2022 | FC Den Bosch | - | VVV-Venlo | 0:2 | ||||
| 17. Round | 11/12/2022 | VVV-Venlo | - | MVV | 2:1 | ||||
| 18. Round | 16/12/2022 | FC Eindhoven | - | VVV-Venlo | 0:2 |
Netherlands