| 1. Round | 11/09/2021 | sc Heerenveen [Youth B] | - | NEC Nijmegen [Youth B] | 5:0 |  |
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| 2. Round | 15/09/2021 | PSV Eindhoven [Youth B] | - | sc Heerenveen [Youth B] | 3:1 | ||||
| 3. Round | 18/09/2021 | sc Heerenveen [Youth B] | - | AZ Alkmaar [Youth B] | 4:2 | |
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| 4. Round | 25/09/2021 | AFC Ajax [Youth B] | - | sc Heerenveen [Youth B] | 2:1 | ||||
| 5. Round | 02/10/2021 | FC Utrecht [Youth B] | - | sc Heerenveen [Youth B] | 2:0 | ||||
| 6. Round | 16/10/2021 | sc Heerenveen [Youth B] | - | PEC Zwolle [Youth B] | 3:0 | |
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| 7. Round | 23/10/2021 | Feyenoord [Youth B] | - | sc Heerenveen [Youth B] | 1:3 | ||||
| 10. Round | 20/11/2021 | sc Heerenveen [Youth B] | - | Feyenoord [Youth B] | 1:3 | ||||
| 11. Round | 27/11/2021 | sc Heerenveen [Youth B] | - | PSV Eindhoven [Youth B] | 4:8 | |
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| 14. Round | 29/01/2022 | AZ Alkmaar [Youth B] | - | sc Heerenveen [Youth B] | 2:1 | ||||
| 13. Round | 05/02/2022 | sc Heerenveen [Youth B] | - | AFC Ajax [Youth B] | 1:1 |
Netherlands