| 1. Round | 03/09/2022 | Feyenoord [U21] | - | FC Groningen [U21] | 5:0 | ||||
| 2. Round | 10/09/2022 | FC Groningen [U21] | - | PEC Zwolle [U21] | 0:0 | ||||
| 3. Round | 17/09/2022 | FC Groningen [U21] | - | Almere City FC [U21] | 2:1 | ||||
| 5. Round | 08/10/2022 | FC Groningen [U21] | - | FC Emmen [U21] | 11:0 |  |
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| 7. Round | 22/10/2022 | FC Groningen [U21] | - | ADO Den Haag [U21] | 3:1 | ||||
| 8. Round | 29/10/2022 | PEC Zwolle [U21] | - | FC Groningen [U21] | 1:1 |  |
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| 9. Round | 05/11/2022 | FC Groningen [U21] | - | Feyenoord [U21] | 1:1 | ||||
| 10. Round | 12/11/2022 | Almere City FC [U21] | - | FC Groningen [U21] | 0:0 | ||||
| 11. Round | 19/11/2022 | FC Groningen [U21] | - | Willem II [U21] | 2:0 | |
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| 12. Round | 26/11/2022 | FC Emmen [U21] | - | FC Groningen [U21] | 2:6 | |
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| 13. Round | 03/12/2022 | ADO Den Haag [U21] | - | FC Groningen [U21] | 0:4 | |
Netherlands