| 1. Round | 12/08/2022 | CA Osasuna | - | Sevilla FC | 2:1 | ||||
| 3. Round | 27/08/2022 | UD Almería | - | Sevilla FC | 2:1 |  |
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| 4. Round | 03/09/2022 | Sevilla FC | - | FC Barcelona | 0:3 | ||||
| 7. Round | 01/10/2022 | Sevilla FC | - | Atlético Madrid | 0:2 | |
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| 8. Round | 08/10/2022 | Sevilla FC | - | Athletic Club | 1:1 | ||||
| 10. Round | 18/10/2022 | Sevilla FC | - | Valencia CF | 1:1 | |
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| 11. Round | 22/10/2022 | Real Madrid | - | Sevilla FC | 3:1 | ||||
| 14. Round | 09/11/2022 | Sevilla FC | - | Real Sociedad | 1:2 |
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