| 1. Round | 07/08/2022 | 1. FC Köln | - | FC Schalke 04 | 3:1 | ||||
| 2. Round | 13/08/2022 | FC Schalke 04 | - | Bor. Mönchengladbach | 2:2 |  |
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| 3. Round | 20/08/2022 | VfL Wolfsburg | - | FC Schalke 04 | 0:0 | ||||
| 4. Round | 27/08/2022 | FC Schalke 04 | - | 1. FC Union Berlin | 1:6 | ||||
| 5. Round | 03/09/2022 | VfB Stuttgart | - | FC Schalke 04 | 1:1 | ||||
| 8. Round | 02/10/2022 | FC Schalke 04 | - | FC Augsburg | 2:3 | ||||
| 9. Round | 08/10/2022 | Bayer Leverkusen | - | FC Schalke 04 | 4:0 | ||||
| 10. Round | 14/10/2022 | FC Schalke 04 | - | 1899 Hoffenheim | 0:3 | ||||
| 11. Round | 23/10/2022 | Hertha BSC | - | FC Schalke 04 | 2:1 | ||||
| 12. Round | 30/10/2022 | FC Schalke 04 | - | SC Freiburg | 0:2 | ||||
| 19. Round | 04/02/2023 | Bor. Mönchengladbach | - | FC Schalke 04 | 0:0 | ||||
| 21. Round | 19/02/2023 | 1. FC Union Berlin | - | FC Schalke 04 | 0:0 | ||||
| 27. Round | 09/04/2023 | 1899 Hoffenheim | - | FC Schalke 04 | 2:0 | ||||
| 29. Round | 23/04/2023 | SC Freiburg | - | FC Schalke 04 | 4:0 | ||||
| 30. Round | 29/04/2023 | FC Schalke 04 | - | Werder Bremen | 2:1 | ||||
| 32. Round | 13/05/2023 | Bayern München | - | FC Schalke 04 | 6:0 | ||||
| 34. Round | 27/05/2023 | RB Leipzig | - | FC Schalke 04 | 4:2 |
Netherlands