| 2. Round | 14/09/2021 | FC Utrecht [U18] | - | sc Heerenveen [U18] | 2:0 | ||||
| 3. Round | 18/09/2021 | Sparta Rotterdam [U18] | - | sc Heerenveen [U18] | 3:1 | ||||
| 4. Round | 25/09/2021 | sc Heerenveen [U18] | - | AZ Alkmaar [U18] | 0:4 | ||||
| 5. Round | 02/10/2021 | PSV Eindhoven [U18] | - | sc Heerenveen [U18] | 5:0 | ||||
| 6. Round | 16/10/2021 | sc Heerenveen [U18] | - | PEC Zwolle [U18] | 3:2 | ||||
| 7. Round | 23/10/2021 | AFC Ajax [U18] | - | sc Heerenveen [U18] | 8:1 | ||||
| 8. Round | 31/10/2021 | sc Heerenveen [U18] | - | PSV Eindhoven [U18] | 1:2 | ||||
| 10. Round | 19/11/2021 | sc Heerenveen [U18] | - | Sparta Rotterdam [U18] | 3:0 | ||||
| 11. Round | 27/11/2021 | sc Heerenveen [U18] | - | FC Utrecht [U18] | 2:0 | ||||
| 9. Round | 30/11/2021 | PEC Zwolle [U18] | - | sc Heerenveen [U18] | 1:0 | ||||
| 14. Round | 19/02/2022 | sc Heerenveen [U18] | - | AFC Ajax [U18] | 0:1 | ||||
| 12. Round | 26/02/2022 | Feyenoord [U18] | - | sc Heerenveen [U18] | 5:2 |  |
Netherlands