1. Round | 17/08/2018 | FC Twente | - | Sparta Rotterdam | 2:1 | ||||
2. Round | 24/08/2018 | Helmond Sport | - | FC Twente | 2:2 | ||||
3. Round | 31/08/2018 | FC Twente | - | Roda JC Kerkrade | 3:1 | ||||
4. Round | 08/09/2018 | FC Twente | - | TOP Oss | 1:2 | ||||
5. Round | 14/09/2018 | FC Dordrecht | - | FC Twente | 0:2 | ||||
6. Round | 21/09/2018 | Telstar | - | FC Twente | 1:3 | ||||
7. Round | 30/09/2018 | FC Twente | - | Jong PSV | 2:1 | ||||
8. Round | 05/10/2018 | FC Eindhoven | - | FC Twente | 1:1 | ||||
9. Round | 14/10/2018 | FC Twente | - | MVV | 0:1 | ||||
10. Round | 22/10/2018 | FC Utrecht (J) | - | FC Twente | 1:6 | ||||
11. Round | 26/10/2018 | FC Twente | - | Almere City FC | 1:0 | ||||
12. Round | 02/11/2018 | FC Twente | - | RKC Waalwijk | 3:1 | ||||
13. Round | 09/11/2018 | FC Den Bosch | - | FC Twente | 2:1 | ||||
14. Round | 18/11/2018 | FC Twente | - | Go Ahead Eagles | 0:1 | ||||
15. Round | 26/11/2018 | AZ Alkmaar (J) | - | FC Twente | 1:2 | ||||
16. Round | 30/11/2018 | FC Twente | - | Jong Ajax | 2:5 | ||||
18. Round | 14/12/2018 | SC Cambuur | - | FC Twente | 0:1 | ||||
20. Round | 13/01/2019 | MVV | - | FC Twente | 0:2 |